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São Paulo med. j ; 124(3): 161-162, May-June. 2006. ilus
Article in English, Portuguese | LILACS | ID: lil-435897

ABSTRACT

CONTEXT: Sarcomatous differentiation, which represents transformation to high-grade malignancy, can occur in all histogical types of renal malignancy. CASE REPORT: The authors report on the case of a 66-year-old woman with a right renal mass that was shown to be a clear cell carcinoma. She underwent radical nephrectomy and dendritic cell vaccination and, 3.5 years later, she developed retroperitoneal pure sarcomatous recurrence of the tumor. The authors speculate that the vaccination could have played some role in this differentiation or selection of the sarcomatous component of the primary tumor.


CONTEXTO: Diferenciação sarcomatosa, que representa evolução para malignidade de alto grau, pode ocorrer em todos os tipos histológicos de câncer renal. RELATO DE CASO: Os autores relatam o caso de uma mulher de 66 anos, com uma massa no rim esquerdo que se revelou um carcinoma de células renais. Após 3,5 anos da nefrectomia radical seguida de vacinação com células dendríticas, a paciente desenvolveu uma recorrência sarcomatosa pura no retroperitônio. Os autores especulam que a terapia com vacina de células dendríticas pode ter desempenhado algum papel na diferenciação ou seleção do componente sarcomatoso do tumor primário.


Subject(s)
Humans , Female , Aged , Cancer Vaccines/therapeutic use , Carcinoma, Renal Cell/pathology , Dendritic Cells , Kidney Neoplasms/pathology , Retroperitoneal Neoplasms/secondary , Sarcoma/secondary , Cancer Vaccines/adverse effects , Carcinoma, Renal Cell/drug therapy , Carcinoma, Renal Cell/surgery , Dendritic Cells/immunology , Kidney Neoplasms/drug therapy , Kidney Neoplasms/surgery , Nephrectomy , Recurrence
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